Boy Scout leaders to vote on lifting gay ban

GRAPEVINE, Texas (AP) ? The Boy Scouts of America will convene a two-day meeting of 1,400 local leaders to consider changing its long-standing ban openly gay boys belonging to the scouting movement.

Officials of the Irving, Texas-based organization are scheduled to open the first of the ballots cast on whether to allow homosexual gay Boy Scouts. Scouting officials propose allowing openly gay Scouts but retaining the ban on gay adult Scout leaders.

The final vote is scheduled for Thursday in the Dallas-Fort Worth suburb of Grapevine.

Some conservatives have denounced the proposal, saying the Scouts' traditions would be undermined by the presence of openly gay youth. Gay-rights supporters have welcomed the proposed change as a positive first step but want the BSA to lift the ban on gay adults as well.

Source: http://news.yahoo.com/boy-scout-leaders-vote-lifting-gay-ban-115130907.html

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Study details genes that control whether tumors adapt or die when faced with p53 activating drugs

May 22, 2013 ? When turned on, the gene p53 turns off cancer. However, when existing drugs boost p53, only a few tumors die -- the rest resist the challenge. A study published in the journal Cell Reports shows how: tumors that live even in the face of p53 reactivation create more of the protein p21 than the protein PUMA; tumors that die have more PUMA than p21. And, for the first time, the current study shows a handful of genes that control this ratio.

"The gene p53 is one of the most commonly mutated cancer genes. Tumors turn it off and then they can avoid controls that should kill them. Fine: we have drugs that can reactivate p53. But the bad news is when we go into the clinic with these drugs, only maybe one in ten tumors actually dies. We wanted to know what genes fine-tune this p53 effectiveness," says Joaquin Espinosa, PhD, investigator at the University of Colorado Cancer Center, associate professor in the Department of Molecular, Cellular and Developmental Biology at CU Boulder, and the paper's senior author.

To answer that question, the group including first author Zdenek Andrisyk, PhD, postdoc in the Espinosa Lab, turned off every gene in the human genome in turn and asked if there were genes that, when deactivated, would tip the balance from p21 to PUMA, thus enhancing the likelihood of cell death.

"We found a couple dozen genes involved in this ratio -- genes that with p53 activated, lead to more p21 and better survival or more PUMA and more cell death," Espinosa says.

The hope is that in addition to drugs that reactivate the tumor-suppressor gene p53, patients could be given a second drug targeting genes that control this p21/PUMA ratio, thus making first drug more effective. Likewise, in cases in which toxicity in healthy tissue limits the use of p53 activating drugs, Espinosa's research could lead to new drugs that thumb the scale of the p21/PUMA ratio toward survival in these healthy tissues. Up or down: learning to adjust the ratio has immense promise.

The group's next step is likely repeating the genetic screen with additional tumor and healthy cell lines to discover which of their newly discovered candidate genes are common controllers of the p21/PUMA ratio across cancer types. And, interestingly, the same technique could be used to make many existing drugs more effective.

"With many of these molecularly targeted therapies, you want one effect but then you end up with many other possible effects," Espinosa says. (An example is the recently-reported side effect of low testosterone in male lung cancer patient taking the molecularly targeted drug crizotinib.) The genetic screening technique used in the Espinosa lab could help disentangle effect from side effect -- showing which secondary genes regulate the desired, tumor-killing response and which secondary genes lead to undesirable side-effects.

"Not only could this technique lead to drugs that decrease the side effects of targeted therapies, but if you're not limited by these side effects, you can simply give more drug, perhaps making existing drugs much more powerful," Espinosa says.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/~3/hkkypGK8KgA/130522123210.htm

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Anthony Weiner is running for mayor of New York City. But, can he win? And does it even matter? (Washington Post)

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Car bombs target Iraqi Shi'ites, killing at least 43

By Kareem Raheem

BAGHDAD (Reuters) - At least 43 people were killed in car bomb explosions targeting Shi'ite Muslims in the Iraqi capital and the southern oil hub of Basra on Monday, police and medics said.

About 150 people have been killed in sectarian violence over the past week and tensions between Shi'ites, who now lead Iraq, and minority Sunni Muslims have reached their highest level since U.S. troops pulled out in December 2011.

No group immediately claimed responsibility for the attacks.

Iraq is home to a number of Sunni Islamist insurgent groups, including the al Qaeda-affiliated Islamic State of Iraq, which has previously targeted Shi'ites in a bid to provoke a wider sectarian confrontation.

Nine people were killed in one of two car bomb explosions in Basra, a predominantly Shi'ite city 20 km (260 miles) southeast of Baghdad, police and medics said.

"I was on duty when a powerful blast shook the ground," said a police officer near the site of that attack in the Hayaniya neighborhood.

"The blast hit a group of day laborers gathering near a sandwich kiosk," he told Reuters, describing corpses littering the ground. "One of the dead bodies was still grabbing a blood-soaked sandwich in his hand."

Five other people were killed in a second blast inside a bus terminal in Saad Square, also in Basra, police and medics said.

In Baghdad, a parked car exploded in a busy market in the mainly Shi'ite eastern district of Kamaliya, killing seven people, police said.

A further 22 people were killed in blasts in Ilaam, Diyala Bridge, al-Shurta, Shula and Sadr City - all areas with a high concentration of Shi'ites.

Iraq's delicate intercommunal fabric has come under increasing strain from the conflict in neighboring Syria, which has drawn Sunni and Shi'ite Muslims from across the region into a proxy war.

Syrian President Bashar al-Assad's main regional ally is Shi'ite Iran, while the rebels fighting to overthrow him are supported by Sunni Gulf powers Saudi Arabia and Qatar.

Iraq says it takes no sides in the conflict, but leaders in Tehran and Baghdad fear Assad's demise would make way for a hostile Sunni Islamist government in Syria, weakening Shi'ite influence in the Middle East.

The prospect of a possible shift in the sectarian balance of power has emboldened Iraq's Sunni minority, embittered by Shi'ite dominance since the overthrow of Saddam Hussein by U.S.-led forces in 2003.

Thousands of Sunnis began staging street protests last December against Shi'ite Prime Minister Nuri al-Maliki, whom they accuse of marginalizing their sect.

A deadly raid by the Iraqi army on a protest camp in the town of Hawija last month ignited a bout of violence that left more than 700 people dead in April, according to a U.N. count, the highest monthly toll in almost five years.

At the height of sectarian violence in 2006-07, the monthly death toll sometimes topped 3,000.

(Additional reporting by Aref Mohammed and Ahmed Rasheed; Writing by Isabel Coles; Editing by Angus MacSwan)

Source: http://news.yahoo.com/two-bombs-kill-11-iraqs-southern-city-basra-071936810.html

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S.Africa central bank sentiment indicator down 1.1 pct in March

JOHANNESBURG (Reuters) - The South African Reserve Bank's monthly leading business cycle indicator fell 1.1 percent in March from February, mainly due to a decrease in the export commodity price index, the bank said on Tuesday.

The indicator collates data such as vehicle sales, job advertisements, business confidence and money supply to gauge the economic outlook.

Indices: 2000 = 100 Jan Feb March

Leading Indicator 103.0 103.0 101.9

12-mth percentage change 1.9 0.9 0.3

Coincident Indicator 112.2 111.7 --

12-mth percentage change 3.1 2.3 --

Lagging Indicator 100.2 101.2 --

12-mth percentage change 0.5 1.8 --

Source: http://news.yahoo.com/africa-central-bank-sentiment-indicator-down-1-1-075855421.html

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About Yohombine Weight reduction Supplement - The Content ...

The Yohimbe tree is a tall evergreen which is native to western Africa. The principal alkaloid present in the bark in the from the West African evergreen Pausinystalia; features a chemical known as Yohimbine. The amount of Yohimbine present in dietary and fat loss dietary supplements, in present day marketplace; may possibly range.

Yohimbine has become utilized as the two an over the counter dietary supplement, as well as being a prescription medication; for that cure of sexual dysfunction. Despite the fact that customarily used in Africa being an aphrodisiac, 1 review identified that oral Yohimbine supplementation may well actuate considerable weight reduction; in athletes. When used being a dietary complement, the dried bark of the Yohimbe tree is employed like a tea and ingested by mouth. In identical vogue, the desired ingredient from the bark is isolated and positioned into capsules and tablets. As these types of, these weightloss health supplements are exceedingly preferred; in the diet plan and bodybuilding communities.

Yohimbine is a psychoactive drug (tryptamine chemical class) with stimulant and aphrodisiac results, and has established for being unsafe; if utilized in excessively. It?s been established the collection among an efficient and risky dose; is incredibly narrow. as well huge of the dosage may be harmful and toxic.
Major negative effects could include things like:

quick heart price,
significant blood strain,
about stimulation,
insomnia, and/or
sleeplessness.
Ahead of consuming any new fat loss tablets, this includes natural wellness products and solutions, speak to the doctor, pharmacist, or other wellbeing treatment supplier. Be selected to convey any well being problems you will have, and consist of information of any dietary supplements; you might currently be taking. In uncommon scenarios, participants expert panic attacks, hallucinations, headaches, dizziness, skin flushing, seizures and renal failure. As such, Yohimbine should not be consumed by any person with liver, kidney, heart ailment, or psychological condition.

More on Yohimbine and Hoodia Gordonii.

Source: http://www.content-dir.com/health-fitness/all-about-yohombine-weight-reduction-supplement/

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Sports world keeps eye on Oklahoma tornado

The massive tornado that ripped through a handful of Oklahoma City suburbs and killed at least 50 people grabbed the attention of the sports world on Monday, especially the players and coaches with ties to the area.

Kevin Durant, a three-time scoring champion for the NBA's Oklahoma City Thunder, posted on his Twitter account that he was praying for everyone involved. He added: "Everybody stay safe!"

Mets pitcher Jeremy Hefner went to Plaza Towers Elementary School in Moore, just south of Oklahoma City. The school had its roof torn off and walls knocked down. Some of those killed died at the school.

"I mean, it's terrifying," the right-hander said.

Hefner still has family living in Moore. He said he had been in contact with his mother, who told him his cousins and uncles were OK.

"It's just unfathomable," he said. "I used to live there."

Dodgers star Matt Kemp posted on Twitter: "'m giving $1000 for tonight's HR and every HR until the All-Star break for the victims of my hometown in OKC. (hash)PrayforOklahoma"

Coverage of the tornado damage was on the clubhouse TV as the Red Sox prepared for their game at the Chicago White Sox.

"It's a tragedy when you see a natural disaster like that take place, so many innocent people that are certainly affected, if not directly by injury or possibly loss of life," Boston manager John Farrell said. "Having been though something similar back in 1997 that had probably very similar damage, it's a scary situation. Our thoughts are with all the people affected."

Farrell played for Oklahoma State in college, and then served as the assistant coach and pitching and recruiting coordinator for the Cowboys for five seasons from 1997-2001.

"The location today is very close to where it was back in '97," Farrell said. "Just that area just south of Oklahoma City seems to be right in the path of unfortunately a lot of storm fronts and certainly the tornadoes again today."

White Sox manager Robin Ventura also played his college ball at Oklahoma State, where was a three-time All-America. The Santa Maria, Calif., native said he didn't know anything about tornadoes until there were a couple that passed through the area while he was in school.

"It's scary," he said. "There's nothing you can do about it."

Browns quarterback Brandon Weeden, who played at Oklahoma State and grew up in the Oklahoma City area, was relieved that no one in his wife's family was injured.

"Devastating damage to Moore, Oklahoma due to Tornadoes," Weeden wrote on his Twitter account. "Please keep these people in your prayers. Thankfully (at)MelanieWeeden family is safe."

Kansas coach basketball coach Bill Self also went to Oklahoma State.

"We wish nothing but the very best for (those affected by the storm) and our thoughts are with them," he said.

Source: http://news.yahoo.com/sports-world-keeps-eye-oklahoma-tornado-050735322.html

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